my yasko results

[Chronicfatiguetreatments]

For any of you that hadnt seen my yasko test results here they are on my blog:
http://www.chronicfatiguetreatments.com ... t-results/

Also they were really difficult to understand so i had Rich Van Konyenburg do a write up and interperet them for me here:

http://www.chronicfatiguetreatments.com ... ase-study/

If you have any test results or questions about the test feel free to post them here

[pyroluria]

I found this site from a Google search that brought me to Rich's interpretation of your results. When I read that I thought this is a forum I want to be a part of.

I haven't done genetic testing yet. I use an orthomolecular approach to treat pyroluria. Ortho also treats high and low histamine levels. Histamine levels relate to under and overmethylation. So I'm tryimg to learn about SNPs to get a sense of the whole picture - all the problems that effect nutrition.

My understanding (and I may be wrong) is COMT is overmethylation (low histamine levels) and MTHFr is undermethylation (high histamine). But these SNPs are still a little confusing to me.

I have Yasko's book but because it lacks a table of contents with page numbers it is a bit of a challenge to use (unless I make my own TOC with pg #s).

I also read Yasko's forum but if I search by SNP initials (COMT or VDR) I get hits for signatures with those SNPs. Posters put their genetic info in their signatures. They don't make it easy to learn this stuff.

But reading the interpretation has me thinking that both high and low histamine levels may be possible at the same time. Food allergies lower histamine levels I've read; so that might explain how those two opposites exit together. I don't know if you have food allergies but that might be one explaination for both SNPs together. I'm not sure if both just exist together to balance each other out. That concept if hard for me to wrap my brain around. I'm still learning this stuff.

High histamine types (histadelics) can have problems with sulfites. Maybe not all though. Molyb helps but if you have a bacterial imbalance but butyrate might help too.

http://www.beatcfsandfms.org/html/HealYourGut.html
(I'm not sure if this link will work.)

Parahprasing -
Your COMT means you are not able to use methyl groups (overmethylation) ...

SAMe makes you spacey - its a methyl donor that overmethylators don't need (they methylate too much and methyl donors make that worse).

But you also have (+/-) MTHFr. You can't process regular folate and need methyl folate (and SAMe).

Because of COMT you don't need methyl donors or methyl forms of b vitamins (methyl B12, 5 MTHF) but MTHFr means you do need SAMe (main methyl donor)and 5 MTHF. This is the part I haven't wrapped my brain around. Understanding histamine levels lead me to believe that a person has either one or the other (high or low levels) but not both together. Apparently both together is possible.

The VDR SNP I think I understand. This means you need D3 and not D2. You may also benefit from vitamin K2 and rosemary and sage. The VDR SNP means vitamin D doesn't get in the cells where it is needed. So its important to take those other things to help vitamin D transport. VDR FOK means you may be prone to diabetes or perhaps problems with your pancreas. Yasko's protocol includes pancreatin for this from what I read on her forum.

The Marshal Protocol is about vitamin D causing problems. I wonder if the Marshall protocol works for those who are VDR positive.

But I did find that interpretation interesting to read. A lot of it was over my head but hopefully I develop an understanding of those other SNPs eventually.

[Chronicfatiguetreatments]

[quote="pyroluria"]
My understanding (and I may be wrong) is COMT is overmethylation (low histamine levels) and MTHFr is undermethylation (high histamine). But these SNPs are still a little confusing to me.
I also read Yasko's forum but if I search by SNP initials (COMT or VDR) I get hits for signatures with those SNPs. Posters put their genetic info in their signatures. They don't make it easy to learn this stuff.
[/quote]

[quote="pyroluria"]
SAMe makes you spacey - its a methyl donor that overmethylators don't need (they methylate too much and methyl donors make that worse).
[/quote]

... one thing im confused about is that sam-e makes me spacey, but the amino acid l-methinonine is one of the things that helps me with brain fog the most. Im pretty sure l-methinonine is a methyldonor. So this doesnt make sense to me at all, but i try to do what my body tells me.


[quote="pyroluria"]
But you also have (+/-) MTHFr. You can't process regular folate and need methyl folate (and SAMe).
[/quote]

...folic acid definately helps me alot. I randomly came across it before i had the yasko test and i gives a good improvement.

[quote="pyroluria"]
Because of COMT you don't need methyl donors or methyl forms of b vitamins (methyl B12, 5 MTHF) but MTHFr means you do need SAMe (main methyl donor)and 5 MTHF. This is the part I haven't wrapped my brain around. Understanding histamine levels lead me to believe that a person has either one or the other (high or low levels) but not both together. Apparently both together is possible.
[/quote]

...the only form of b12 i can tolerate is hydroxycobalamin, the other forms make me feel over stimulated. but , the hydroxy form gives me a big improvemnt. The shots especially. I also take the sublingual form.

[quote="pyroluria"]
The VDR SNP I think I understand. This means you need D3 and not D2. You may also benefit from vitamin K2 and rosemary and sage. The VDR SNP means vitamin D doesn't get in the cells where it is needed. So its important to take those other things to help vitamin D transport. VDR FOK means you may be prone to diabetes or perhaps problems with your pancreas. Yasko's protocol includes pancreatin for this from what I read on her forum.
[/quote]

I havent really havent even tried supplements to address this snippet. I still take all the yasko vitamins, but im focusing now on the martin pall supplements, and i read this is an interaction between nitric oxide and the methylation cycle, so it seem to make sense that both of these would help.
There was a diagram i found of how they interacted, but i cant find it right now.

thanks for your intereretation though, its nice to have some input on that. It is so tough to understand.

[pyroluria]

That's interesting about SAMe but not methionine causing problems. I think SAMe is more active than methionine. That's another way of saying methionine has to be converted to SAMe in the body. I know that William Walsh of the Pfeiffer Treatment Center recommends SAMe early in the treatment process. Using methionine might take longer to see progress than SAMe for undermethylators.

But you might be considered someone who has high histamine levels but not that high perhaps. That's my way of making sense of the combo of COMT and MTHFr.

Folate in any form is important for methylation. Undermethylators and over methylators need it. The form that is right for each person is the issue really.

Hydrox B12 works for COMT types. Other forms can be (too) stimulating for COMT types I've read. Both COMT and VDR can have too much catecolamines from other forms I think.

Martin Pall's info is interesting and important I think especially for those with multisystem issues or long term infections. His theory is that elevated brain NO is caused by long term infection or severe oxidative stress. He recommends lots of supplements and one or two antibiotics.

http://chronicfatigue.about.com/od/trea ... otocol.htm

Pall says that hydroxy B12 (OH-Cbl) is an important scaveneger of brain NO. It converts into gluthioninecobalamin as an intermediate step. I think that is the benefit of the OH-Cbl. (I think a patent for gluthioninecobalamin is in the works.) So maybe elevated NO levels is an issue for you.

Yasko's protocols, from what I read, are progressive, meaning you add in one supplement at a time and/or you address one SNP at a time. So not taking any VDR supplements isn't surprising or out of the norm I think. Balancing all the SNPs can be an issue. Some types for example need sulfur but can also have trouble processing sulfur; so it can be a process of taking each step of the methylation cycle and addressing that with supplements one step at a time.

Yeah its complicated and not that easy to understand. I'm trying to learn the SNPs one by one I guess. But there are a number of them which can make looking at these altogether a bit overwhelming. I think this concept helps me understand why Yasko's protocol is slow in adding in supplements. Each SNP is like a separate condition that needs to be addressed separately before adding in the supplements for another SNP. Try too many supplements at once and you can't figure out exactly where the problem is. This is definitely a complex process. Orthomolecular conditions are simple compared to this stuff but at least understanding ortho stuff I got some basics in understanding methylation. Its complex but fascinating as well.

[Chronicfatiguetreatments]

[quote="pyroluria"]
Martin Pall's info is interesting and important I think especially for those with multisystem issues or long term infections. His theory is that elevated brain NO is caused by long term infection or severe oxidative stress. He recommends lots of supplements and one or two antibiotics.

Pall says that hydroxy B12 (OH-Cbl) is an important scaveneger of brain NO. It converts into gluthioninecobalamin as an intermediate step. I think that is the benefit of the OH-Cbl. (I think a patent for gluthioninecobalamin is in the works.) So maybe elevated NO levels is an issue for you.[/quote]

I think im going more in the martin pall NO direction, but ive had benefit on some of the supplements, but not all. Ive been taking flavinox and that has helped me alot. Its supposed to inhibit inos (nitric oxide from macrophages).
But the other anti-oxidantslike Co-q10, and alpha lipoic acid work in the short term, but after a few days i feel really fatigued, so i decide just to stick with flavinox and b12 for now.
Ive been reading about another supplemnt that inibits inos called aminoguanidine. It would be interesting to try this and see if it had the same effect as the flavinox.