Ive always had a favorable response to B12. It improves all of my symptoms, especially brain fog. I finally got to try my first Hydroxocobalamin B12 shot (after having to convince my Dr.) and within a couple hours my brain fog feels much improved. My genetic test results from amy yasko showed that i have a mutation in the gene MTRR that recycles b12.
So these shots may be very beneficial me.
From what i have read, b12 is very helpful to most cfs patients. The reasons that it might help is that b12 is a scavanger for the free radicals nitric oxide and peroxynitrite. Nitric oxide can caused decreased barin fuction and also can
increase sesitivity to pain. Certain doctors like Martin Pall believe that free radicals may be the cause of CFS. Dr. Pall cured himself of CFS by the use of antioxidants like CoQ10, Vitamin e, Flavinox, NaC, EPA fish oil, acetyl-l-carnitine and Alpha lipoic acid.
B12 is an extremely safe supplement and is not toxic at any level. Any extra b12 that the body doesnt need is excreted though urine. Sublingual b12 is also very helpful, if you dont have access to injections. There are also a few different forms of b12 that might be more appropriate for certain issues.
Hydroxocobalamin – This is the form that i was prescribed. If you feel over-stimulated from the other form, this is the one you should take. My genetic test showed that i may have high levels of serotonin and dopamine, and hydroxocobalamin doesnt have methyl groups.
Methylcobalamin – This is the form that my Dr. first recommended. She believed it was the most active, but for me the methyl form was overstimulating and i had to take the hydrox form. This may be the most expensive also, due to the fact that it has to be made in completely sterile conditions.
Cyanocobalamin – This is the most used form and possibly the cheapest. I also took a shot of this form and it worked well for me.