B12 Injections…Wow « Chronic Fatigue Syndrome Blog

B12 Injections…Wow

b12 injection Ive always had a favorable response to B12. It improves all of my symptoms, especially brain fog. I finally got to try my first Hydroxocobalamin B12 shot (after having to convince my Dr.) and within a couple hours my brain fog feels much improved. My genetic test results from amy yasko showed that i have a mutation in the gene MTRR that recycles b12.
So these shots may be very beneficial me.
From what i have read, b12 is very helpful to most cfs patients. The reasons that it might help is that b12 is a scavanger for the free radicals nitric oxide and peroxynitrite. Nitric oxide can caused decreased barin fuction and also can
increase sesitivity to pain. Certain doctors like Martin Pall believe that free radicals may be the cause of CFS. Dr. Pall cured himself of CFS by the use of antioxidants like CoQ 10, Vitamin e, Flavinox, NaC, EPA fish oil, acetyl-l-carnitine and Alpha lipoic acid.

B12 is an extremely safe supplement and is not toxic at any level. Any extra b12 that the body doesnt need is excreted though urine. Sublingual b12 is also very helpful, if you dont have access to injections. There are also a few different forms of b12 that might be more appropriate for certain issues.

Hydroxocobalamin - This is the form that i was prescribed. If you feel over-stimulated from the other form, this is the one you should take. My genetic test showed that i may have high levels of serotonin and dopamine, and hydroxocobalamin doesnt have methyl groups.

Methylcobalamin - This is the form that my Dr. first recommended. She believed it was the most active, but for me the methyl form was overstimulating and i had to take the hydrox form. This may be the most expensive also, due to the fact that it has to be made in completely sterile conditions.

Cyanocobalamin - This is the most used form and possibly the cheapest. I also took a shot of this form and it worked well for me.

5 Comments »

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Comment by Jen

July 15, 2008 @ 6:58 pm

I have extremely terrible fatigue and have been taking b12 injections. (regular) (along with the long list of everything else…) I am taking all the sublinguals of the different b12s, but I am wondering if they might work better in injection form. Can you tell me why your dr. was resistant to prescribing this type of b12 injection? Is it working better?

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Comment by admin

July 15, 2008 @ 7:42 pm

hi jen,
my dr. didnt think that hydro b12 worked as well as methyl or cyano. She said that methyl was by far the most active form.

Ive tried the hydrox and cyano forms. The hydrox didnt help that much over the long term, it is less stimulating, but didnt help as much as the cyano. I think there reason i noticed more of an improvement that i was talking about it above, was because i accidentally injected it into a big vein in my leg.

Not really sure, but i switched back to the cyano and it work alot better for me.

Also the hydrox and methyl forms are very expensive.
But my insurance paid for some of it.

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Comment by taniaaust1

October 20, 2008 @ 9:37 pm

Hi there great site and very helpful too. As a CFSer of 11 years, Im thinking about doing one, more sites like this are needed.. Thank you for yours.

I’ve been experiementing with Cyanocobalamin injections and are finding them so far helpful to my memory and mindfog. I can actually now do very simple maths in my head again due to them . So far thou they havent helped my energy or anything else. Due to a MTHFR polymorpism, I should be having the Methylcobalamin to donate methyl group.

In my case no doctor would agree to allow me to try B12 injections, (my memory issues were so bad that I couldnt even remember at times what simple objects were or even looked like), so out of desperation, I started doing this treatment myself. (Here in Australia one dont need a script to get these ampules).

I have no real idea how much of these most CFSers are taking? or what the recommendations of dosage are for this?. What were you told as far as how often to have this?? (I notice it worn off within 4-5 days).

Thanks..

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Comment by Admin

October 21, 2008 @ 12:32 am

i take them 2 times a week. I do 1 cc each shot.
I do notice that they wear of after a week or so.

My dr. did say that i could take as much as i needed, because your body just urinates out the excess. But i also heard that there is a very small risk of eye nerve damage with the cyanocobalamin form. So maybe you dont want to take huge doses. Ask your Dr. about that.

Im taking the hydroxy form and it is less stimulating that the cyano form. Which was good for me because i felt kind of nervous on the cyano form.

But it definately helps alot.

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Comment by Susan

November 7, 2008 @ 2:42 pm

I want to add a very important factor in taking a B-complex whenever taking the components of B vitamins. If you take only components (B-6, B-12, ect..) seperate, it will leach out all the other B vitamins if you don’t take a B-complex once a day. Just makes sense not to just take one component without the whole B vitamin.
Just a word of wisdom to always seek the natural in its complete form.

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