Comments on: An Engineering Perspective on CFS – by Dave Whitlock

By: CFSBOSTON

CFSBOSTON — Sun, 27 Nov 2011 19:19:39 +0000

There is no mystery to Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), as so many people will have you think. CFS/ME leads to HIV-Negative AIDS (i.e., idiopathic CD lymphocytopena), a clinical diagnosis that I currently possess.

It horrifies me on a regular basis that the medical establishment, politicians, and media have not gotten around to reporting the fact that HIV is not the cause of AIDS.

While millions of ailing CFS/ME patients get purposefully belittled and neglected, perfectly healthy HIV+ people are convinced to take a bunch of expensive, toxic medication. What a $ham.

I am living proof that CFS/ME patients are the real AIDS patients, while existing AIDS patients simply have CFS/ME.

See how easy? Mystery solved.

http://www.cfsstraighttalk.blogspot.com

Perhaps now, AIDS funding can be redirected to CFS/ME where it truly belongs. And HIV+ people, well, they should seriously just walk away from this nonsense.

By: Grey

Grey — Sun, 12 Jun 2011 13:52:23 +0000

While I don’t know of any ways to increase NO levels, I was just reading that ginger, the root, lowers NO levels. Impounder if anyone has noticed ginger worsening their symptoms.

By: daedalus2u

daedalus2u — Sat, 24 Jul 2010 18:40:07 +0000

Tom, yes, adrenaline has the effect of lowering NO levels.

Yes, brain fog is mediated through low NO in the brain, it isn’t via vasoconstriction (but vasoconstriction does accompany low NO). It is mediated through the low NO more directly. I have a blog about the effects of NO on brain function.

http://daedalus2u.blogspot.com/2008/01/resolution-of-asd-symptoms-with-fever.html

NO is what mediates functional connectivity in the brain, so with low NO, there is less connectivity and the brain is unable to achieve its normal levels of computation.

By: Tom

Tom — Sun, 18 Apr 2010 18:01:54 +0000

Hi David, with your knowledge of chemistry and physiology do you know if increased adrenaline levels could have an affect of reducing NO levels? And also if reduced levels of NO is seen in CFS do you think symptoms could also be due to vasoconstriction, say perhaps cerebral and the complaint of “brain fog” and reduced cognitive function? Thanks for your thoughts! Tom

By: daedalus2u

daedalus2u — Mon, 14 Sep 2009 17:53:01 +0000

The only reference I have been able to find on mitochondria turnover is this

http://www.jbc.org/cgi/content/abstract/246/8/2425

where they do show very high turnover rates, with a half life in the liver and kidneys on the order of 10 days.

I would like better data on it too, but the tests are all destructive, so we are unlikely to see them in humans as they would be unethical to the point of criminality.

By: JD

JD — Mon, 13 Jul 2009 15:14:05 +0000

Thanks for sharing your thoughts. (I am a former ChemEng myself) I have no interest in CFS, I was just searching the web for some mitochondria turnover data, there does not seem to be any credible data on the subject, or even what the definition of ‘turnover’ is (if the same damaged proteins or mtDNA is just recycled into another mitochondria is that really turnover?). fwiw… A mitochondria half life of 18 days would equate to a turnover of 3%/day (not the 6% stated in your post), perhaps you meant to say 9 days. Regardless, IMO, those turnover rates seem unfathomably high for humans, particularly human skeletal muscle. And I would think that such a high turnover rate would negate any correlation between mitochondria and any chronic condition. I am not being critical of your post in any way, I am just venting a little that there is no credible data or consensus on such a fundamental biological process.

By: chris

chris — Tue, 16 Dec 2008 22:14:02 +0000

hi–
interesting–
so will b12 shots be harmfull as they scavenge no?
thanks chris

By: daedalus2u

daedalus2u — Thu, 04 Dec 2008 15:23:58 +0000

There was just a recent article in Nature that pretty strongly supports a low NO connection to mild exercise induced fatigue. Here is the abstract:

http://www.nature.com/nature/journal/v456/n7221/abs/nature07414.html

and here is the editors summary (I subscribe to Nature, so it isnâ€™t clear to me what non-subscribers have access to).

http://www.nature.com/nature/journal/v456/n7221/edsumm/e081127-16.html

If NO is involved in the normal regulation, then low NO will affect that regulation and skew it in a characteristic direction and cause these symptoms to some degree.

By: ducky

ducky — Tue, 11 Nov 2008 13:35:25 +0000

what about the NO precursors arginine and citrulline? They improve endothelial response.

I think CFS also involves precursor (stem) cells all over the body.

Something kills the stem calls, even n the bone marrow and brain, and the body has problems with cell repair because of that.

By: Elisabeth

Elisabeth — Sat, 08 Nov 2008 22:58:27 +0000

Thank you so much for writing about CFS and your theory. It is fasinating…

I look forward to hearing more!

Thanks