Home / D-Ribose


d-riboseD-Ribose is a sugar (derived from glucose) that has been shown to boost levels of the energy compound ATP. Some studies have shown that CFS patients have lower than normal levels of ATP and D-Ribose could be used to increase energy production in the muscles and heart.

The increased levels of ATP may help relieve fatigue by provide the muscles with extra energy. D-Ribose also helps the body to recycle ATP, and use its own energy it has more efficiently.

A study by well know chronic fatigue specialist Dr. Jacob Teitelbaum, has shown D-ribose to improve sleep, fatigue, concentration, pain and well-being in patients.

The Study:

- There were 36 patients in this study
- The average age of the participants was 48 and was 78% female.
- The patients in this study took D-Ribose at a dose of 5 grams, three times each day.


- 69% of the 36 patients had significant improvement. They had 25% improvement in the quality of life, as compared to before the study.

Ribose has also been used in sports to enhance athletic ability. It can also be used to treat a genetic disorder called myoadenylate deaminase deficiency. In this disorder, a sufferer is deficient in an enzyme called AMP deaminase. A deficient person can have symptoms like energy problems and muscle cramping.

How is D-Ribose Ingested?

This substance can be taken in powder form and mixed into liquid like juice or water. It also can be given intravenously.

Recommended Dosages

The dosages doctors recommend can vary greatly. To enhance performance for athletics some have advised 5 grams daily. But for other medical issues like CFS or heart failure, some doctors have recommended 15-30 grams per day. Speak with your doctor before ingesting any supplements, including ribose.

Other Supplements That May Increase ATP

One supplement that may increase ATP is the antioxidant CoQ10. It is required by all cells to produce ATP inside the mitochondria. CoQ10 may be beneficial to people with certain medical conditions like heart failure. ATP is in very high demand in certain organs like the heart, so supplementation with ribose or CoQ10 has been shown to been helpful in improving “ischemic threshold” and enhancing “diastolic function” in certain studies.

Can this Supplement Increase Blood Sugar?

This substance is a sugar, so diabetics should be wary of how it can affect their bodies. There currently have not been any studies done on blood sugar and d-ribose, so it’s effect are not completely known.


The effectiveness of this supplement on patients with chronic fatigue syndrome seem to be mixed. Some have noticed improvement, while others notice no effect or jitteriness. It does not seem like this is the answer that CFS patients have been looking for, but it may provide some relief of symptoms like low energy.

Try our Sublingual Methyl B12 here, if you are looking to improve energy levels and concentration. It is one of the most effective supplements for CFS that we have seen, it is by no means a cure, but can help some symptoms.

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63 Responses to “D-Ribose”

  1. Chris says:

    Great replies here about Ribose. I tried it a few years ago, and for some reason it gave me weird brain symptoms. Felt a bit off/odd for some reason! Never heard of this in anyone before. Since then tho got full blown adrenal insufficiency and have been on hydrocortisone for 2.5 years. This unfortunately has made all my CFS symptoms worse, PARTICULARLY brain fog/dysfunction. I’m guessing it’s because of my poor liver detox/drug processing capability. Trying a few new things soon, and re-trying Ribose to see how it goes a few years later. I never got past 2-3 days because of the strange feelings. Hoping I can give it a full month or so and see if it improves things after that time as others above have mentioned. Worth it when nothing else helps much! Oh I must add that Methylation suppliments have helped me more than anything so far – especially DMG. I take it with B12/folic sublinguals. DMG really can help prevent the “CFS” crash and sustain energy longer. I’d def try it if you havent!

  2. Karen says:

    I tried d-ribose last summer and it didn’t help at all. I was fine beginning in Aug. of this year but I began crashing in late March. I’ve just recently seen an Endocrinologist who tested my vit. D, growth hormone, and I had the ACTH test – which all came back fine as usual. I was a bit upset with the endo. she basically told me this was all in my head. Especially when I told that I was taking anti-depressants for my CFS. Anyways, not sure what else to do. I’ve reduced my stress as much as I can. Does anyone have any other ideas?

  3. Ace says:

    Tried D-ribose for a few days and I don’t like it at all… making me light-headed and not giving me energy.. it might help some percentage of the population, but not all..

  4. Bill says:

    I have ME/CFS for 10 years plus…

    I began taking D-Ribose Chewable 2 weeks ago. I am taking 1 to 2 of the recommended 3 times a day 1,500 mg. When I take one I have a 2-3 hour window of energy boost. Enough energy that I am now able to go to the gym and do a nice upper body workout. I seem not able to tolerate cardio type exercises like the exercise bike. The only cardio I can do without crashing is the Viper Rope Pull down machine. I am currently slowly building up with resistance bands and lite weight machines.
    I am going into this because pre D-Ribose I could tolerate going to the gym maybe once a month if at all. In the 2 weeks on D-Ribose I have gotten to the gym twice each week.
    Sleep – I am also sleeping better, instead of sleeping 2-3 hours at a time. I am now sleeping 4-6 hours at a time. Vast improvement,
    Brain Fog – I am now able to focus better on a tasks.
    I got the chewable from kind of icky tasting but it’s worth it. Will try pills next time.

  5. Sue S says:

    RE: Anna S.- I also had polio at age 9 months. A couple of years ago I was ill with the flu. I thought I had overcome the flu within a week but it went stealth in my body-I also drank soy milk which I later found was contaminated with hexane. At any rate, I developed a myo-fascial condition which I am still overcoming gradually. In the past I found that whey, creatine, & glutamine made my muscles real strong but I am allergic to dairy products so could not continue this supplement. I have found the malic acid & Magnesium SRT, B vitamins, collagen, silica, spirulina, Bos-Cur and green tea theoflavins, MSM etc all helpful.
    I have not tried the ribose yet. It seems odd to me and I wonder why that would be of more benefit than Niacin.

  6. rayford J says:

    i have just started D-Ribose and it gives me an almost immediate mental clarity and focuse that I did not get with adderall. I have not yet tried for deep sleep nor for physical energy(hiking), however if it’s giving me the energy and clarity that i lacked i will continue to invrease the dose until I can find the correct dosage for me. I would imagine everyone’s reaction to be different, but at this time and 2 grams per day, I feel better.

  7. Sandi says:

    I need to know if this weill affect my blood sugar as i am a type 2 diabetic and my sugar readings are high….i have tried the d-ribose before as i have fibromyalgia and it helped greatly, however i need to watch my blood sugar levels too…..can anyone shed some light on this????? Please?

  8. SueEllen says:

    I just came across this article so wanted to comment on D-Ribose as I have CFS did try it a couple of times. I took it in the high quality powder form, and had no positive effect whatsoever. In fact it made me feel lightheaded as though my blood sugar was too low. I took it for about a month and then gave up unable to tolerate it. I think the statistics of how many people improved are a little fabricated just like Dr. T’s statistics for improvement in his patients who pay thousands at his treatment clinics.

  9. Ange says:

    I got CFS like symptoms after an infection after surgery and was in bed for 5 months, no amount of rest was making me feel better. I was tested for everything and was only slightly vitamin d deficient. I read online about taking Ribose along with L-Carnitine, CoQ10 and Magnesium. The miracle 4! I don’t think Ribose on its own is enough to build the 4 building blocks for ATP energy – you need all 4. So, I took all 4 together and within a few weeks I started to notice a difference and that I was getting my energy back. It was amazing to be able to walk up stairs and feel like I could go and see my friends for a few hours. Within a couple of months I was back to a fairly normal lifestyle with energy to do things and not get wiped out for a whole week! That was a 2 years ago… and now I just have to take the miracle 4 whenever my energy levels start to dip every once in a while.

  10. Polly says:

    Just tried ribose and it made me dizzy and then very tired. think is a blood sugar thing. i have cfs so Will give it a longer go and take it with food next time.

  11. Adrian says:

    I have Type 1 diabetes and also heart failure. In my opinion D-Ribase is an excellent remedy and does what it says on the tin. However you need to use it with other supplements too. You need to take Vitamin C (at least a gram a day for the Krebs cycle) and also Magnesium and CoEnzyme Q10. In addition you need a good range of B vitamins, especially B3 and B12. You will also benefit from other anti-oxidants and from helping your liver to detox. Do all this and the D-Ribose will certainly boost your ATP levels. That, believe me, is something worth having as it cures tired legs and really boosts your heart.

  12. Joyce says:

    I won’t try it because it is corn based (and I have a corn allergy), and also recently found out by testing my own glucose levels (and through a program by Dr. Ritamarie Loscalzo) that I’m on the edge of insulin resistance. If your fasting glucose levels are higher than 90 (US) or 5 (CAnada), you might want to be careful with this sugar. Read Dr. Mark Hyman’s book on the Blood Glucose Factor. I do better on MCT oil that provides ketones to brain tissue damaged by head trauma prior to CFS onset.

  13. Sonya says:

    For the gals that had issues with feeling dizzy or low blood sugar when taking ribose: I took Corvalen (ribose purchased through my doctor) and it states on the jar to take with meals or food because it can cause low blood sugar. So that may help.

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