SOunds like we have the same response to the NO drugs like arginine, caffine, horny goat weed, etc…. where I feel good crash.

However, what caught my attention was the b-vitamins. Have you had anymore luck with the B-12 etc?

I had good luck with the NAC and alpha lipoic acid/l carnitine for ahwile. my sex drive improved, energy increased, mood improved. however, it came to an end with like buring, feet burning, bladder burning. SOund familiar to anyone else? Those symptoms are relieved by methyl b-12, by the way. SO I am trying to figure out why.

Thanks
Mark

I’ve had a long battle with CFS. I was ill for probably all my life until I found a great doctor in NY. He diagnosed me as having HHV-6, Candida, CMV, Epstein-Barre and hypothyroidism and food allergies. I started with detoxing with UltraClear and then used Borage Oil, Cal/Mag, CoQ10, Armour thyroid, T-Cell formula, Vit C, Acidophilus, Chromium Picolinate. This was in 1993. I was also thereafter diagnosed 5 separate times with Lyme disease and treated with high dosages of antibiotics. I responded quickly, lost 30 lbs. and was fine for years. Recently I am quite ill again and can not figure out what triggered it. I had stopped taking all supplements a few years ago except for the thyroid. Now I’m gluten intolerant, have high blood pressure, high cholesterol, and I think I have candida again. I’ve gained 40 lbs. I tried the blood type diet which is really bad for someone who is not healthy. Now I realize I am still harboring all these viruses and am trying to get back on track.In 1993 there was no way to even know all this stuff! Thank goodness for the internet.

I’ve tried allopathic doctors here in California, but none of them are CFS informed. Since I didn’t feel that badly, I skated along, but now that I’m sick I’m searching for a good doc. Too bad the tests are so expensive. I tried a naturpath but I think she’s not informed either. Why do lab tests have to be doctor ordered? If you’re willing to pay, I don’t see why patients can’t order them. Oh well.

My latest blood work was rather useless. Only an IgE allergy test was performed, and I have delayed food allergies which requires an IgG test, but my insurance company doesn’t cover them. My metabolic panel turned out normal!!! But I had an EIS test done (an electro interstitial scan) and it completely disagreed with the lame blood tests. For example, the blood tests said my sodium and potassium were normal, but the EIS revealed that my sodium is high and my potassium is low. So make sure you get good testing done, not the average doctor’s tests.

Does Dr. Yasko have tests other than the genetic one? I’m sure my insurance company wouldn’t pay for that.

So now I’m actually moving over to Dr Pall’s protocol – listed here http://molecular.biosciences.wsu.edu/Faculty/pall/pall_main.htm – as I’m convinced he’s cracked it; and adding the low dose Folapro and Folinic acid from Kronyenberg’s protocol every other day, or every three days, just to ease out the intensity of the early detox reaction.
I think both protocols work on the same principles, only Kronyenberg’s seems to kick start the internal detox mechanisms aggressively, while Pall’s seems to be more about supporting them… Both down-regulate the NO/ONOO cycle… I think in both cases, as Dr Pall says, you can’t expect to make significant progress unless you tackle as many parts of the cycle as possible at once, as well as avoiding exposure to anything which might increase/sustain damage (emotional stress, excessive exercise, chemicals/toxins, etc.)…

After 6 years of trying everything under the sun, I think these protocols which focus on strict pacing & avoidance of stressors, the NO/ONOO cycle and raising glutathione, will be refined and improved, and I wouldn’t be surprised if they become to chronic/multisystems illnesses what antibiotics are to chest infections… Feeling incredibly positive about these!

Quick update anyway. I went off the Yasko supplements for a bit because I figured I needed to take care of digestive issues first; not wanting a double die-off what with taking Caprylic acid for Candida.

Started the Yasko up again with the addition of the quarter pill Folapro (Folate), and wow, that seems to step things up another notch.

If anything, it’s how bad they’re making me feel which is so encouraging… I’ve felt sort of pre-viral since going back with the additional Folate, which suggests to me my immune system is dealing with infections, (for a change)…

I’ve figured the best way is to take it easy and slowly add and take away supplements, but I look back to a few months ago and there’s certain things I’m not getting so much now – despite feeling worse than usual. My fatigue’s always bad with the Yasko supp’s, but it’s of a tired, sluggish nature; relaxing fatigue really; certainly not the sick feeling, unpleasant fatigue I used to get quite frequently.

Recovery time from stress/exercise seems to have improved too. Response to stress seems reduced too.

Early days, but of all the treatments I’ve tried so far, this seems like it might be getting to the bottom of things… While the Sinatra Protocol supplements seem to be a great support package – seem to have more consistent days; less ups and downs…

I’ve been taking active B6 (Pyridoxyl-5-phosphate, 50mg) for a while anyway, added methylcobalamin (B12, 1mg) sublingual – no problems… Then yesterday, for the first time, I tried Folinic Acid, 400mcg (the active form of Folic Acid) for the first time, and 12 hours later I felt like I was coming down with flu.

I’m going to lay off it for a few days; continue with general mitochondrial support (Ribose, Q10, Carnitine, B3, Magnesium – which has been fantastic so far) before going at it again… I’ve read this acute detox/immune reaction is a good sign – it means your immune system’s working again! So I’m really interested to see how it goes now.