Ive been writing about Nitric Oxide and the “Martin Pall model of CFS” for a while. The reason i am so interested in it is that it makes sense with my symptoms and treatments that benefit me.
Ive been sick for 8 1/2 years and throughout that time i have come across 7 supplements that really help. Before i read Dr. Pall’s theory, I had no idea why they helped. I had tried literally 100’s of pills and i noticed that these few things improved my symptoms. I started reading about how these supplements affect the body, and they all have 1 thing in common. They all affect nitric oxide.
I recently added the supplement Flavinox (which is a part of Dr. Pall’s suggested treatment regimen). This supplement is made of 7 herbs/supplements which contain high levels of Flavinoids. Flavinoids, it turns out inhibit iNOS, which is a type of nitric oxide made by the macrophages in the immune system.
I noticed a difference right away. Flavinox helps brain fog, makes me feel relaxed, and my sleep is the best it has been in years.
Yesterday I found a paper which makes me feel like more CFS research is moving towards Pall’s NO/ONOO cycle theory. This paper talks about how the tricyclic antidepressant trazodone may effect nitric oxide signalling. Which, could be the reason it and other tricyclic antidepressants (elavil, sinequan, trazodone) can have beneficial effects on CFS patients.
I found another recent paper on fatigue and nitric oxide in the medical journal Nature. It’s just an excerpt, but it talks about how nitric oxide in certain conditions can cause the blood vessels to fail to relax normally after exercise and contribute to fatigue. Could this contribute to what is happening with brain bloodflow in CFS patients?
One more thing i’ve been thinking about is that there are many people in the forums that have had benefits from Ashok Gupta’s program. Its been shown that meditation ( increases nitric oxide) and Gupta’s techniques may help CFS in that respect. So, all of these things together seem to suggest that nitric oxide is very important to CFS.
**note – i’m a not a doctor, im just writing this all down so i can keep it straight in my own head.
“i have come across 7 supplements that really help.”
…so why not list them?
Sorry to pick, but the blog articles here keep eluding to your personal solutions, which you fail again and again to describe, and instead generally refer to them. Why?
I agree. What ARE the supplements??